In the present study, extraction of lithium from salts obtained from brine desalination in Gohar Zamin iron ore mine (Sirjan) was investigated using D2EHPA extractant solvent and kerosene diluent. This laboratory-scale study included 29 sets of experiments using a solvent extraction system. To perform the desired extraction experiments, equal volumes of the aqueous phase (10 ml) were contacted with the organic phase (D2EHPA + kerosene) at a specified concentration and then subjected to stirring in a magnetic stirrer for 30, 45, and 60 minutes at laboratory temperature (23 °C). In this investigation, was utilized form Box-Behnken (response surface design) to optimize and assessment of main variables influence of solvent extraction process such as pH, organic to aqueous phase ratio, stirring time, and D2EHPA percentage on lithium recovery. The linear interference model (2FI vs Linear) was applied as the response for lithium recovery. The accuracy and validity from this model were evaluated using variance analysis (ANOVA). According to the process results, optimal operating conditions for lithium recovery were 69.81% at condition of volume of D2EHPA extractant of 29.2%, pH of 5.6, organic to aqueous phase ratio 3:1, and 52.05 min stirring time. The results illustrated that the stirring time had a smaller effect than the two variables of extractant amount and ratio of O/A. The organic to aqueous phase ratio index O/A was more effective than other parameters on lithium recovery.